Rare brain disorder linked to coronavirus infection claims child’s life in China

Doctors in China have documented a tragic case where an eight-year-old girl died after the COVID-19 virus infected her brain, triggering a rare and deadly neurological complication. The case, published in a medical journal, highlights an uncommon but severe side effect of the virus that dominated global health concerns for nearly two years and is currently experiencing a resurgence in several regions.

According to medical records from the Guangzhou Women and Children’s Medical Centre, the young patient initially presented with fever accompanied by multiple seizures. Her symptoms included headache, vomiting, and a distinctive bumpy rash covering her arms, legs and torso. Due to the absence of an “identifiable trigger,” healthcare providers did not immediately test her for COVID-19, a decision that may have delayed a critical diagnosis.

Rapid neurological deterioration followed initial symptoms

The girl’s condition deteriorated rapidly, requiring intubation after she began “frothing at the mouth” while her “limbs stiffened and shook” during acute episodes. Subsequent testing revealed she was suffering from acute necrotising encephalopathy (ANE), with COVID-19 infection identified as the “likely” cause when her test results came back positive, according to the case study published in BMC Infectious Diseases.

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Despite aggressive medical intervention, the child remained in a profound coma without sedation. Just nine days after her initial symptoms appeared, physicians declared her brain dead, and she was removed from life support.

Scientific understanding of COVID’s neurological impacts still evolving

Research has demonstrated that the COVID-19 virus can penetrate the blood-brain barrier and cause various neurological complications, as reported by Mail Online. Clinicians at Guangzhou Women and Children’s Medical Centre acknowledged that the medical community is still working to determine optimal treatment protocols for pediatric COVID-19 patients experiencing “rapid-onset neurological decline.”

Although laboratory analysis also detected traces of rotavirus in the patient’s blood and stool samples, treating physicians concluded that the COVID-19 infection was the more probable cause of the fatal neurological complications.

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What is acute necrotising encephalopathy?

Acute necrotising encephalopathy occurs when the immune system mounts an excessive response to viral infections such as COVID-19 or influenza. This hyperinflammatory reaction damages tissues throughout the body. When this process affects the brain, toxins and bacteria penetrate brain tissue, causing cerebral swelling and cellular death.

Medical experts classify this condition as extremely rare, with approximately only one hundred documented cases in scientific literature.

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